Name
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Icon
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Description
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Globin Goo
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When Isaac dies, he will transform into goo similar to a Globin. If Isaac doesn't take damage for 3 seconds while in this state, he will morph back to normal.
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Split Cross
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Isaac's tears now have a chance to split in midair depending on luck and distance.
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Ponger
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Isaac gains pixel tears that shoot at 45 degree angles which also bounce off walls.
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Salt
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Isaac gains a damage up whenever he misses a shot, which caps at +5. Isaac will then explode and his damage will slowly reduce back to his normal damage.
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Ring of Fire
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Isaac gains a flaming orbital for every room that he clears.
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SUPER POWERS!
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Gives a unique effect for every single character. (Read more about the effects on the SUPER POWERS! page.)
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Cursed Bone
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Isaac will now shoot black bones which have a low chance of becoming cursed bones, which, when hit, transforms enemies into charmed Bonies.
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Lost Courage
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Isaac gains an unknown power...
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Lost Wisdom
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Isaac gains an unknown power...
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Lost Power
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Isaac gains an unknown power...
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Hellbeam
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Isaac shoots Brimstone lasers up from the ground, similar to the effect and controls of Epic Fetus.
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Poison Ray
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Isaac can shoot a beam that will poison enemies.
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Beginner's Luck
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Isaac gains a varying amount of luck based on the current floor, the maximum being +10 luck in Basement I. The luck bonus goes down by 1 after every floor, eventually no longer giving any bonuses.
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Cute Bombs
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Isaac's bombs become Cute Bombs which charm enemies upon exploding.
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Lucifer's Wallet
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Causes devil deal items to be purchased with coins instead of hearts.
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Technology 3
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Isaac can now charge up his shots to fire a burst of technology lasers in rapid succession. This item does not need to be fully charged to fire, similar to Tech X.
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Tech Boom
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Isaac's bombs now shoot out lasers in random directions before they explode.
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Azazel's Lost Horn
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Isaac gains a short range Brimstone laser similar to Azazel.
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Dyslexia
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Pickups now randomly give either a key, bomb or coin. Heart pickups will randomly be red or soul hearts.
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Deja Vu
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Isaac is granted double damage in any rooms he has already visited.
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Chameleon
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Upon getting hit by an enemy, Isaac will no longer get hurt by that enemy type until he is hit by another enemy. Ineffective against bosses.
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Tetrachromacy
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Isaac now shoots eight color-switching tears at once.
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Oven Mitt
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Fire Resistance.
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Cursed Contract
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Spawns 2 Devil Room items.
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Lightshot
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Isaac now fires angelic lasers that pierce enemies and do damage per second.
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Satan's Chalice
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When Isaac is at full health, any red hearts picked up will become orbitals that block up to two hits.
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Evil Options
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All Devil Rooms have 4 devil deals.
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Zeus Touch
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When Isaac takes damage, lightning strikes from above.
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Explosive Temper
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After a certain amount of time shooting tears, Isaac explodes, dealing no damage to himself. After exploding, there is a cooldown time where Isaac can not shoot.
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Rare Key
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Lets you fight Serpent.
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Black Belt
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Gives Isaac a random collectible at the beginning of the next floor if he doesn't take damage for the entirety of the current floor.
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Rainstorm
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Tears fall from the sky in random locations after Isaac takes damage.
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Rain Boots
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When tears hit an enemy, it creates a puddle. Stepping in the puddle will splash tears in all directions.
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Cute Dress
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When wearing this, any enemy that damages you will be "shamed". Shamed enemies will be attacked by other enemies until they die.
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Sad Heart
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Gives Isaac +1 heart and +1 damage.
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Armor of Ares
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Isaac gains 1+ Damage and causes 2 collectibles to spawn in Challenge Rooms.
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Bandana
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When you are attacked, you have a chance (based on luck) to not take damage, and kill (or damage bosses) the enemy that attacked you.
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Purple Belt
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When you take damage, all enemies freeze, neither taking nor dealing damage except for the one that hurt you. Once that one is dead, the rest unfreeze.
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Water Balloon
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Turns Isaac's tears into water balloons that fire in an arc and break into a splash of short ranged tears when landing.
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Eternal Resurrection
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Isaac now gains extra lives from eternal hearts, rather than health ups.
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Virtue of Patience
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All stats up when all red heart containers are full, stat boost amount based on how many red hearts you have.
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Even More Options!
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The first time an item pedestal would spawn this floor a second item also spawns.
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Quake Shot
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Isaac's tears are replaced with shockwaves that must be charged, the shockwaves break rocks and open stone chests.
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Dad's Moustache
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Isaac can now shoot tears directly behind him in 3 directions.
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Puke
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Isaac's tears now occasionally shoot out 2 at a time, with a slight delay between them.
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Sparkle Bombs
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Isaac's bombs turn gold. When exploding, any enemy caught in the explosion is turned into a gold statue. If they are killed by the explosion, they drop coins.
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Skippy Tears
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Tears bounce when they hit the ground and become smaller the more they bounce. +5 tear delay and range down.
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Inferno Soul
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Spawns an orbital familar that turns any tears that pass through it into Fire Mind tears.
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